Publications

To view a full list of our publications on PubMed, click here.

Selected Publications 

  1. Habaz IA, Ou X, Wang NI, Schincaglia A, Shydlouskaya V, Mahendran A, Martinez-Santiesteban FM, Doolabi D, Bao Y, Movasseghi AR, Haruna J, Power NE, Scholl TJ, Huynh MJ, Sener A, Haeryfar SMM: MAIT cells promote cancer progression and regulatory T cell accumulation in bladder tumor microenvironment. Journal for ImmunoTherapy of Cancer 2025, 13(9):e012496. PMID: 40954074
  2. Rashu R, Ninkov M, Wardell CM, Benoit JM, Wang NI, Meilleur CE, D’Agostino MR, Zhang A, Feng E, Saeedian N, Bell GI, Vahedi F, Hess DA, Barr SD, Troyer RM, Kang CY, Ashkar AA, Miller MS, Haeryfar SMM: Targeting the MR1-MAIT cell axis improves vaccine efficacy and affords protection against viral pathogens. PLoS Pathogens 2023, 19(6):e1011485. PMID: 37384813
  3. Routy B, Lenehan JG, Miller WH, Jamal R, Messaoudene M, Daisley BA, Hes C, Al KF, Martinez-Gili L, Puncochar M, Ernst S, Logan D, Belanger K, Esfahani K, Richard C, Ninkov M, Piccinno G, Armanini F, Pinto F, Krishnamoorthy M, Figueredo R, Thebault P, Takis P, Magrill J, Ramsay L, Derosa L, Marchesi JR, Parvathy SN, Elkrief A, Watson IR, Lapointe R, Segata N, Haeryfar SMM, Mullish BH, Silverman MS, Burton JP, Maleki Vareki S: Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial. Nature Medicine 2023 (in press) (PMID: 37414899)
  4. Ninkov M, Schmerk CL, Moradizadeh M, Parvathy SN, Figueredo R, Burton JP, Silverman MS, Fernandes R, Maleki Vareki S, Haeryfar SMM: Improved MAIT cell functions following fecal microbiota transplantation for metastatic renal cell carcinoma. Cancer Immunology, Immunotherapy 2023, 72(5):1247-1260. PMID: 36396738
  5. Choi J, Schmerk CL, Mele TS, Rudak PT, Wardell CM, Deng G, Pavri FR, Kim K, Cepinskas G, He W, Haeryfar SM: Longitudinal analysis of mucosa-associated invariant T cells in sepsis reveals their early numerical decline with prognostic implications and a progressive loss of antimicrobial functions. Immunology & Cell Biology 2023, 101(3):249-261. PMID: 36604951
    • Selected by the Australian and New Zealand Society for Immunology (ASI) as one of the Top 10 Articles Published in Immunology & Cell Biology (between July 1, 2022 and June 30, 2023)
  6. Yao T, Rudak PT, Laumont CM, Michaud AR, Rashu R, Knier NN, Foster PJ, McWilliam HEG, Villadangos JA, Nelson BH, DiMattia GE, Shepherd TG, Haeryfar SMM: MAIT cells accumulate in ovarian cancer-elicited ascites where they retain their capacity to respond to MR1 ligands and cytokine cues. Cancer Immunology, Immunotherapy 2022, 71(5):1259-1273. PMID: 34854949
  7. Rudak PT, Choi J, Parkins KM, Summers KL, Jackson DN, Foster PJ, Skaro AI, Leslie K, McAlister VC, Kuchroo VK, Inoue W, Lantz O, Haeryfar SMM: Chronic stress physically spares but functionally impairs innate-like invariant T cells. Cell Reports 2021, 35(2):108979. PMID: 33852855
  8. Kim GN, Choi JA, Wu K, Saeedian N, Yang E, Park H, WooSJ, Lim G, Kim SG, Eo SK, JeongHW, Kim T, Chang JH, Seo SH, Kim N, Choi E, Choo S, Lee S, Winterborn A, Li Y, Parham K, Donovan JM, Fenton B, Dikeakos JD, Dekaban GA, Haeryfar SMM, Troyer RM, Arts EJ, BarrSD, Song M, Kang CY: A vesicular stomatitis virus-based prime-boost vaccination strategy induces potent and protective neutralizing antibodies against SARS-CoV-2. PLoS Pathogens 2021, 17(12): e1010092. PMID:34914812
    • Featured in the CIHR Institute of Infection and Immunity (III) E-Bulletin on January 13, 2022
  9. Choi J, Mele TS, Porcelli SA, Savage PB, Haeryfar SMM: Harnessing the versatility of invariant NKT cells in a stepwise approach to sepsis immunotherapy. The Journal of Immunology 2021, 206(2): 386-397. PMID: 33310870
  10. Rudak PT, Yao T, Richardson CD, Haeryfar SMM: Measles virus infects and programs MAIT cells for apoptosis. The Journal of Infectious Diseases 2021, 223(4): 667-672. PMID: 32623457
    • Featured in an invited live interview broadcast by Global News Radio 980 CFPL on December 23, 2020
    • Covered by London Free Press in an article entitled “Measles vaccine found to protect immune response” on December 30, 2020
    • Featured in the CIHR Institute of Infection and Immunity (III) E-Bulletin on June 3, 2021
  11. Yao T, Shooshtari P, Haeryfar SMM: Leveraging public single-cell and bulk transcriptomic datasets to delineate MAIT cell roles and phenotypic characteristics in human malignancies. Frontiers in Immunology 2020, 11: 1691. PMID: 32849590
  12. Meilleur CE, Memarnejadian A, Shivji AN, Benoit JM, Tuffs SW, Mele TS, Singh B, Dikeakos JD, Topham DJ, Mu HH, Bennink JR, McCormick JK, Haeryfar SMM: Discordant Rearrangement of Primary and Anamnestic CD8+ T Cell Responses to Influenza A Viral Epitopes Upon Exposure to Bacterial Superantigens: Implications for Prophylactic Vaccination, Heterosubtypic Immunity and Superinfections. PLoS Pathogens 2020 May 20, 16(5):e1008393. [PMID: 32433711]
  13. Meilleur CE, Wardell CM, Mele TS, Dikeakos JD, Bennink JR, Mu HH, McCormick JK, Haeryfar SM: Bacterial superantigens expand and activate, rather than delete or incapacitate, preexisting antigen-specific memory CD8+ T Cells. The Journal of Infectious Diseases 2019, 219(8): 1307-1317 [PMID: 30418594]
  14. Memarnejadian A, Meilleur CE, Shaler CR, Khazaie K, Bennink JR, Schell TD, Haeryfar SM: PD-1 blockade promotes epitope spreading in anticancer CD8+ T cell responses by preventing fratricidal death of subdominant clones to relieve immunodomination. The Journal of Immunology 2017, 199(9): 3348-3359 [PMID: 28939757]
  15. Shaler CR, Tun-Abraham ME, Skaro AI, Khazaie K, Corbett AJ, Mele T, Hernandez-Alejandro R, Haeryfar SM: Mucosa-associated invariant T cells infiltrate hepatic metastases in patients with colorectal carcinoma but are rendered dysfunctional within and adjacent to tumor microenvironment. Cancer Immunology, Immunotherapy 2017, 66(12): 1563-1575 [PMID: 28798979]
  16. Shaler CR, Choi J, Rudak PT, Memarnejadian A, Szabo PA, Tun-Abraham ME, Rossjohn J, Corbett AJ, McCluskey J, McCormick JK, Lantz O, Hernandez-Alejandro R, Haeryfar SM: MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: defining a novel mechanism of superantigen-induced immunopathology and immunosuppression. PLOS Biology 2017, 15(6): e2001930 [PMID:28632753]
  17. Szabo PA, Goswami A, Mazzuca DM, Kim K, O’Gorman DB, Hess DA, Welch ID, Young HA, Singh B, McCormick JK, Haeryfar SM: Rapid and rigorous IL-17A production by a distinct subpopulation of effector memory T lymphocytes constitutes a novel mechanism of toxic shock syndrome immunopathology. The Journal of Immunology 2017, 198(7): 2805-18 [PMID:28219889]
  18. Szabo PA, Rudak PT, Choi J, Xu SX, Schaub R, Singh B, McCormick JK, Haeryfar SM: Invariant NKT cells are pathogenic in the HLA-DR4-transgenic humanized mouse model of toxic shock syndrome and can be targeted to reduce morbidity. The Journal of Infectious Diseases 2017, 215(5): 824-9 [PMID:28035011]
  19. Szabo PA, Goswami A, Memarnejadian A, Mallett CL, Foster PJ, McCormick JK, Haeryfar SM: Swift intrahepatic accumulation of granulocytic myeloid-derived suppressor cells in a humanized mouse model of toxic shock syndrome. The Journal of Infectious Diseases 2016, 213(12): 1990-5 [PMID:26908735]
  20. Memarnejadian A, Meilleur CE, Mazzuca DM, Welch ID, Haeryfar SM: Quantification of alloantibody-mediated cytotoxicity in vivo. Transplantation 2016, 100(5): 1041-51 [PMID:26985743]
  21. Maleki Vareki S, Harding MJ, Waithman J, Zanker D, Shivji AN, Rytelewski M, Mazzuca DM, Yekta MA, Chen W, Schell TD, Haeryfar SM: Differential regulation of simultaneous antitumor and alloreactive CD8+ T-cell responses in the same host by rapamycin. American Journal of Transplantation 2012, 12(1): 233-9 [PMID:22026814]
  22. Hayworth JL, Mazzuca DM, Maleki Vareki S, Welch I, McCormick JK, Haeryfar SM: CD1d-independent activation of mouse and human iNKT cells by bacterial superantigens. Immunology and Cell Biology 2012, 90(7): 699-709 [PMID:22041925]
  23. Walker KM, Rytelewski M, Mazzuca DM, Meilleur SA, Mannik LA, Yue D, Brintnell WC, Welch I, Cairns E, Haeryfar SM: Preventing and curing citrulline-induced autoimmune arthritis in a humanized mouse model using a Th2-polarizing iNKT cell agonist. Immunology and Cell Biology 2012, 90(6): 630-9 [PMID:21912419]
  24. Mannik LA, Chin-Yee I, Sharif S, Van Kaer L, Delovitch TL, Haeryfar SM: Engagement of glycosylphosphatidylinositol-anchored proteins results in enhanced mouse and human invariant natural killer T cell responses. Immunology 2011, 132(3): 361-75 [PMID:21070234]
  25. Chau TA, McCully ML, Brintnell W, An G, Kasper KJ, Vines ED, Kubes P, Haeryfar SM, McCormick JK, Cairns E, Heinrichs DE, Madrenas J: Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome. Nature Medicine 2009, 15(6): 641-8 [PMID:19465927]
  26. Haeryfar SM, Lan Z, Leon-Ponte M, Duffy KR, Ge W, Liu W, Mele T, Garcia B, Wang H*: Prolongation of cardiac allograft survival by rapamycin and the invariant natural killer T cell glycolipid agonist OCH. Transplantation 2008, 86(3): 460-68 [PMID:18698251]
  27. Haeryfar SM, Hickman HD, Irvine KR, Tscharke DC, Bennink JR, Yewdell JW*: Terminal deoxynucleotidyl transferase establishes and broadens anti-viral CD8+ T cell immunodominance hierarchies. The Journal of Immunology 2008, 181(1): 649-59 [PMID:18566432]
  28. Haeryfar SM, DiPaolo RJ, Tscharke DC, Bennink JR, Yewdell JW: Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities. The Journal of Immunology 2005, 174(6): 3344-51 [PMID: 15749866] 
  29. Tscharke DC, Karupiah G, Zhou J, Palmore T, Irvine KR, Haeryfar SM, Williams S, Sidney J, Sette A, Bennink JR, Yewdell JW: Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines. The Journal of Experimental Medicine 2005, 201(1): 95-104 [PMID:15623576]
  30. Haeryfar SM, Al-Alwan MM, Mader JS, Rowden G, West KA, Hoskin DW: Thy-1 signaling in the context of costimulation provided by dendritic cells provides signal 1 for T cell proliferation and cytotoxic effector molecule expression, but fails to trigger delivery of the lethal hit. The Journal of Immunology 2003, 171(1): 69-77 [PMID:12816984]